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RIT1 regulation of CNS lipids RIT1 deficiency Alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities.
Wu L, Wang F, Moncman CL, Pandey M, Clarke HA, Frazier HN, Young LEA, Gentry MS, Cai W, Thibault O, Sun RC, Andres DA. Wu L, et al. Heliyon. 2023 Sep 23;9(10):e20384. doi: 10.1016/j.heliyon.2023.e20384. eCollection 2023 Oct. Heliyon. 2023. PMID: 37780758 Free PMC article.
Oligodendrocytes (OLs) generate lipid-rich myelin membranes that wrap axons to enable efficient transmission of electrical impulses. Using a RIT1 knockout mouse model and in situ high-resolution matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-M …
Oligodendrocytes (OLs) generate lipid-rich myelin membranes that wrap axons to enable efficient transmission of electrical impulses. Using a …
IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade.
Mir S, Cai W, Carlson SW, Saatman KE, Andres DA. Mir S, et al. Sci Rep. 2017 Jun 12;7(1):3283. doi: 10.1038/s41598-017-03641-9. Sci Rep. 2017. PMID: 28607354 Free PMC article.
When compared to wild-type HNPCs, RIT1 (-/-) HNPCs show deficient IGF-1-dependent Akt signaling and neuronal differentiation, and accordingly, Sox2-dependent hippocampal neurogenesis is significantly blunted following IGF-1 infusion in knockout (RIT1 (-/-) ) mice. C …
When compared to wild-type HNPCs, RIT1 (-/-) HNPCs show deficient IGF-1-dependent Akt signaling and neuronal differentiation, and acc …
Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells.
Custer SK, Gilson TD, Li H, Todd AG, Astroski JW, Lin H, Liu Y, Androphy EJ. Custer SK, et al. PLoS One. 2016 Oct 13;11(10):e0163954. doi: 10.1371/journal.pone.0163954. eCollection 2016. PLoS One. 2016. PMID: 27736905 Free PMC article.
We identified SMN-dependent splicing changes, including an intron retention event that results in the production of a truncated Rit1 transcript. This intron-retained transcript is stable and is mis-spliced in spinal cord from symptomatic SMA mice. Constitutiv …
We identified SMN-dependent splicing changes, including an intron retention event that results in the production of a truncated Rit1 …
Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.
Arlotta P, Molyneaux BJ, Chen J, Inoue J, Kominami R, Macklis JD. Arlotta P, et al. Neuron. 2005 Jan 20;45(2):207-21. doi: 10.1016/j.neuron.2004.12.036. Neuron. 2005. PMID: 15664173 Free article.
Loss-of-function experiments in null mutant mice for Ctip2 (also known as Bcl11b), one of the newly characterized genes, demonstrate that it plays a critical role in the development of CSMN axonal projections to the spinal cord in vivo, confirming that we identified …
Loss-of-function experiments in null mutant mice for Ctip2 (also known as Bcl11b), one of the newly characterized genes, demonstrate that it …